Understanding the genetics of Alzheimer’s Disease in social contexts- Gene x Environment interactions and their social implications

Our research aims to shed some light on the genetic and environmental factors that influence the onset and progression of Alzheimer’s Disease (AD). The pioneering work of the Cardiff based CADR team has led to the discovery of over 40 genes that contribute to a person’s risk of developing AD. Data about these genes gathered from the CADR early-onset Alzheimer’s disease (EOAD) and Cognitive Function and Aging Studies (CFAS) Wales cohorts will be used to build mathematical models that will be able to predict the likelihood of an individual developing AD. We will then examine how lifestyle factors such as an individual’s social environment interact with genetic risk calculated with these models.

Collaboration

To identify and recruit participants for this study requires close collaboration with NHS Health boards and trusts across Wales, England and Scotland.

Highlights

  • Testing of relationships between genetic findings and clinical and environmental factors.
  • Dissemination of findings through public engagement events.
  • Continuing to build a valuable store of biological samples for future research.

We are looking for people with Alzheimer’s disease and healthy controls to help us with our research. Individuals with Alzheimer’s disease with an onset of symptoms before the age of 70, and healthy individuals without any memory problems over the age of 80. If you are interested in finding out more about our research you can contact the Cardiff University Dementia Research team on 02920 688042 or via email at ADresearch@cardiff.ac.uk

 

For information on our past research please click these links: 

Further Understanding the Genetics of Alzheimer's Disease

Translation of Genetic findings into clinical and social impact

CRISPR/Cas9 Genome Editing to Model AD Risk Variants with Isogenic Pluripotent Stems Cells