Professor Valentina Escott-Price
Professor, Dementia Research Institute My main research interest is to deploy the new opportunities afforded by technological advances and large sample sizes in order to contribute to the identification of new risk genes and biological pathways for psychiatric and other disorders and to undertake integrative analyses to provide additional biological meaning to the basic genetic data. As a member of several international consortia, we analyse terabytes of genome/exome/sequencing data for cohorts of tens of thousands of individuals from different populations. Being a member International Genomics of Alzheimer's Project (IGAP) consortium, we processed and analysed genome-wide data which resulted in the discovery of 11 new susceptibility loci for Alzheimer's disease. Further analysis of this data, with the approximate gene-based analysis, which we developed in 2011 in Cardiff, lead to the discovery of two additional Alzheimer's disease susceptibility genes. My most recent research is focused around the evaluation of genetic risk associated with different aspects of psychiatric and neurological diseases. In our recent work, we have investigated the polygenic architecture of Alzheimer's and Parkinson’s diseases and have also explored the potential relationship between an individual’s polygenic risk score and the risk of the disease.